Description
IWR-1 is a potent small-molecule inhibitor of tankyrase 1 and 2 (TNKS1/2), key regulators of the Wnt/β-catenin signaling pathway. By stabilizing Axin and promoting β-catenin degradation, IWR-1 effectively suppresses canonical Wnt signaling, making it a valuable tool for studying pathway modulation in cancer, stem cell biology, and developmental research.
IWR-1 is widely used in cell-based assays to investigate Wnt-driven processes, including cell proliferation, differentiation, and tumorigenesis. Its reversible and selective mechanism enables precise control of pathway activity, supporting both mechanistic studies and drug discovery applications.
Key Features:
- Potent inhibitor of tankyrase (TNKS1/2)
- Suppresses Wnt/β-catenin signaling via Axin stabilization
- High activity in cell-based assays
- Useful for cancer, stem cell, and developmental biology research
- Suitable for screening and pathway validation studies
Applications:
- Wnt signaling pathway research
- Cancer biology and tumor progression studies
- Stem cell differentiation and maintenance
- Drug discovery and target validation
Formulation & Storage:
- Typically supplied as a solid powder
- Soluble in DMSO
- Store at -20°C, desiccated, and protected from light
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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