Technology | Monoclonal antibody platform SBEAD

 Single B-cell Express Antibody Discovery (SBEAD)

SBEAD is a cross species (rabbit, mouse, llama and more) platform for monoclonal antibody development. When used in rabbits, our special rabbit strains or transgenic lines can be used to further enhance the antibody capability. The advantages of the platform include: 

- High and broad affinity. The KD values of the most SBEAD developed rabbit mAbs are at or lower than 10-10M. Low or medium affinity antibodies are also available. 

- Unlimited supply. Customer owns the IP of the selected antibody sequences. Recombinant antibodies can be produced unlimitedly. 

- Fast turnaround. 11 weeks from immunization to the delivery of ELISA positive antibodies for customer’s in house screening. 3 weeks for the sequencing and production of the selected antibodies. (Comparison: single B cell culture method >18 weeks; surface display method >21 weeks; hybridoma method >25 weeks) 

- More clones. >500 ELISA positive antibodies can be provided at customer’s request. 

- Large quantity. ?g each recombinant antibodies will be provided for screening, enough for most assays including functional tests. (Comparison: single B cell culture generate mostly <100 ng). 

- Accuracy. Antibody samples are quantified in concentration and antigen binding before they are provided for customer screening. 

- Convenience. Antibodies can be provided with luciferase fusion to facilitate customer’s in house screening