Monoclonal antibody development

ATGC is dedicated to provide the top quality monoclonal antibody service to the biomedical community. The features of our SBEAB platform include high affinity, fast speed and quantitative antibody screening. We are also pioneers in transgenic rabbit techniques and provide various special rabbit strains and transgenic lines for antibody development. Besides rabbits, our experts also have extensive experience in single domain antibody (nanobody) development from alpaca. Check Technologies for details of our SBEAD monoclonal antibody development platform. The workflow, timelines and deliverables are listed in the following chart. Please contact us with your project details:

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Workflow, timeline and deliverables

Customer provided antigen

Protein or protein conjugate

3.5mg, >0.5mg/ml in PBS

3mg for immunization; 0.5mg for screening

Stage 1: animal immunization

Accelerated immunization (rabbit and mouse) : 1 animal, 4 weeks
Classical immunization : 1 animal, 9 weeks
Delivery: serum titer report

Stage 2: single B cell cloning

2 weeks
Delivery: ELISA positive recombinant mAbs
Delivery: mAb concentration and antigen binding report

Customer in house screening

Select clones of interest

Stage 3: antibody sequencing & production

3 weeks
Delivery: Sequences of selected antibodies
Delivery: >0.5mg each of selected antibodies

Additional services

Antibody expressing plasmid construction
Stable antibody expressing cell line generation
Antibody pair screening
Other antibody tests